Cells within a tumor are not the same; they may have different genetic mutations and different characteristics during growth and throughout treatment. These differences make treating tumors extremely difficult and often lead to tumor recurrence dominated by more aggressive tumor cells. Moffitt Cancer Center researchers are using mathematical modeling to characterize these differences within a tumor and hope that the results of their latest study will lead to better therapeutic treatments.
“Many tumors exhibit different metabolic behaviors compared to normal tissue; they consume more of the nutrient glucose and produce acid as a byproduct. This leads to an acidic environment that tumor cells are better adapted to live in and promotes the development of invasive cells.” said Mark Robsertson-Tessi, Ph.D., an applied research scientist in the Integrated Mathematical Oncology (IMO) Department at Moffitt.